Cristiana is a 30 year old woman, brought up in a "proper", bourgeois middle-class family. Her time is split between writing for her PhD in Earthquake Engineering, conversations with Alex and Michelle, her two close friends and occasional, eagerly awaited rendezvous' with Dan, a married man with whom she is romantically involved. After her parents move out of the family apartment into a new house, she decides to get a dog. It is something that she wanted ever since she was a child and now that she lives on her own she can finally fulfill this wish.

After suffering terrible headaches and stomach cramps, Mr. Lăzărescu, a lonely 63 year-old man, calls for an ambulance, beginning one man’s hellish journey through Bucharest hospitals in search of proper medical care. As the night unfolds, his health starts to deteriorate fast.