Best friends Emily and Lesley go on a road trip to the desert. When Emily decides to get off the highway and take a "short cut," they become the target of a relentless and psychotic trucker who forces them to play a deadly game of cat and mouse.

This deliriously offensive, gory horror-comedy features an underground comic book artist whose obscene caricature upsets a crime lord, who responds by cutting off the young man’s hand. The young man wallows in post-severed hand depression. Will criminality reign supreme? Will he live alone as a bitter one-handed man? Not if the slightly rotted hand, now alive and determined to exact revenge, teems up with his former body and a masked S&M gay superhero to rid the city of evil.

A seasoned news correspondent and cameraman embed themselves with a posse that set off into the rugged wilderness of the Rocky Mountains to find a missing child who may become the next victim of what is believed to be a rogue grizzly...