The story revolves around a Basque Roman Catholic priest dedicated to committing as many sins as possible, a death metal salesman from Carabanchel, and the Italian host of a TV show on the occult. These go on a literal "trip" through Christmas-time Madrid to hunt for and prevent the reincarnation of the Antichrist.

Jose, a journalist and radio broadcaster, runs a daily program under the title 'Alone in the wee hours' ('Solos en la madrugada'), which has garnered a huge national audience as a satirical chronicle of Spanish society in the democratic transition of the late 1970s. Married and separated from Elena, Jose has two children, whom he only sees from time to time. Then he meets Maite, younger than him, outgoing and more open-minded than he wants. The emotional shock caused by his relationship with these two women will change his pessimistic view of life.