A drug experiment gone wrong produces a league of blood-thirsty zombies. It is up to a small band of exotic dancers trapped in a gentleman's club to fight back. Together they must rely on their wits and skills to survive the night, and pray that they don't become victims of the flesh-eating zombies!

Heather is an exotic dancer who has become a vampire and works at a nightclub named Vamps, managed by her fiancé Seamus, a defrocked priest. They learn that they have made a powerful enemy in Elizabeth, another comely female vampire whose sister was killed by the denizens of Vamps years before. Elizabeth is eager to get revenge against Heather and her fellow vampire strippers, especially since Heather and Seamus could possibly bring about the Prophesy of the Redeemer, which would bring an end to vampires once and for all.

A public relations firm is really a front for a devil-worshiping cult that kidnaps young models to sacrifice to the devil. A reporter stumbles onto their operation.

Tasha runs a strip club which contains a few vampire strippers. She is well aware of the bloodsucker problem as she is one herself. Heather is an all-American girl who applies for a job to pay her way through school. She is hired but it doesn't take long for Tasha to decide that they should suck Heather into their clan. Only a faltering priest named Seamus can save Heather from the horrible prospect of eternal life.