Following the death of her father in a terrible accident, sweet, yet troubled Jennifer and her friends decide to check out her dad's cabin that's located in the deep woods of Boggy Creek, Texas. While staying at said cabin for a week, Jennifer and company run afoul of an evil and vicious monster of local legend that kills men and abducts women.

While searching for a "cure all" serum, Dr. Edward Kanopolus, "Dr. K", is being pressured for results by the pharmaceutical company funding the project. With time running out, tragedy and desperation drive him to make decisions that will jeopardize the lives of everyone around him and ultimately unleash a terrifying monster on a killing spree.