Chaos consumes a small town when a chemical facility explodes releasing a deadly toxin. Moments after the leak, the town's residents show signs of mutation, causing the military to quarantine the area leaving any survivors helpless and trapped inside. The story follows Jim, a young man isolated within the red zone, as he eludes flesh eating zombies in an attempt to win back his freedom.

Barry Munday, a libido-driven wage slave who spends all his time either ogling, fantasizing about or trying to pick up women, wakes up in hospital after a freak attack only to find that his testicles have been removed.

Wiley Roth finds a severed human finger in his kitchen one night. Understandably freaked out, in a search across Los Angeles that brings them in contact with psychics, ineffectual police, crooked taxidermists, mysterious neighbors who might be on drugs, and a nine-fingered woman named Cheryl who might, improbably, end up being the girl of his dreams.

Thanks to an auto accident, a parasitic alien manages to get into a hospital. It quickly moves from the crash victim into a candy striper. Among the patients at the hospital are some rather short high school basketball players. It is through them that we watch the events unfold. The infected, or inhabited, candy striper becomes predatory. She goes after men for sex and after women to spread. Infected women develop an incredible sweet tooth and devour anything sweet they can find. The horror then spreads. As the horror takes over more of the hospital and the CDC locks it down, the basketball players and a few friends do everything they can to try and get out of the hospital. But soon it becomes evident that the problem has spread too far. Now if they manage to escape it will only be to delay the inevitable if they cannot halt the spread of aliens before they get out and take over the whole world.

Over Thanksgiving weekend, all but five students in an old Manhattan building that's now a college dormitory leave for home: staying on one floor are roommates Lauren, Melina, and Alison, plus her boyfriend Diego and Grant, a loner in a room down the hall. Lauren's been seeing things in her bathroom: a silent child of about six. Diego has written a paper on parapsychology, so he holds a séance with the disbelieving co-eds. Something goes awry, because bad things start to happen and the students' only defender is an aging campus cop named Syd. What's the silent ghostly girl's secret, and can Alison discover what's going on before it's too late?

An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.