During an experiment gone bad, radiation turns a scientist into a raging green behemoth whenever he becomes agitated. Unable to control his transformations, David Banner searches for a cure as he crosses the country, fugitive-style, with a dogged tabloid reporter on his trail.

When the relatives of a recently deceased voodoo priestess gather at her sinister house on Skull Mountain for the reading of the will, they discover a killer in their midst who wants to keep them from collecting their inheritance.