When struggling filmmaker inadvertently records a notorious serial killer in the middle of a murderous act, he decides to use the footage to blackmail the madman into being the subject of a disturbing new documentary.

Told from the points of view of both the Baltimore homicide and narcotics detectives and their targets, the series captures a universe in which the national war on drugs has become a permanent, self-sustaining bureaucracy, and distinctions between good and evil are routinely obliterated.

Suburbanite Ron is spoiled, young and not overly worried about the marijuana charges leveled against him. But, after being made out to be a drug dealer, he faces a five-year jail sentence in San Quentin State Prison. Physically frail and unaccustomed to his rough surroundings, Ron is primed to fall victim to sexual predators and bullying guards – that is, until he's befriended by Earl, a veteran inmate who finds meaning in protecting the vulnerable new kid.

In the criminal justice system, sexually-based offenses are considered especially heinous. In New York City, the dedicated detectives who investigate these vicious felonies are members of an elite squad known as the Special Victims Unit. These are their stories.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly, and patient Jeffrey Goines, the son of a famous virus expert, who may hold the key to the mysterious rogue group, the Army of the 12 Monkeys, thought to be responsible for unleashing the killer disease.