Two New Orleans paramedics' lives are ripped apart after encountering a series of horrific deaths linked to a designer drug with bizarre, otherworldly effects.

In the pre-Civil War United States, Solomon Northup, a free black man from upstate New York, is abducted and sold into slavery. Facing cruelty as well as unexpected kindnesses Solomon struggles not only to stay alive, but to retain his dignity. In the twelfth year of his unforgettable odyssey, Solomon’s chance meeting with a Canadian abolitionist will forever alter his life.