A married workaholic, Michael Newman doesn't have time for his wife and children, not if he's to impress his ungrateful boss and earn a well-deserved promotion. So when he meets Morty, a loopy sales clerk, he gets the answer to his prayers: a magical remote that allows him to bypass life's little distractions with increasingly hysterical results.

After five (or six) years of vanilla-wedded bliss, ordinary suburbanites John and Jane Smith are stuck in a huge rut. Unbeknownst to each other, they are both coolly lethal, highly-paid assassins working for rival organisations. When they discover they're each other's next target, their secret lives collide in a spicy, explosive mix of wicked comedy, pent-up passion, nonstop action and high-tech weaponry.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.