The Fugitive Task Force relentlessly tracks and captures the notorious criminals on the Bureau’s Most Wanted list. Seasoned agent Jess LaCroix oversees the highly skilled team that functions as a mobile undercover unit that is always out in the field, pursuing those who are most desperate to elude justice.

High school guidance counselor Jeff and his platonic friend and co-worker Anne are responsible, well intentioned, kind… and boring. They frustratingly watch on as their peers find love and companionship, while they continue to fail in spectacular fashion when it comes to romance. As they reach their loneliness breaking point, they make a pact to forgo their familiar, vanilla personas in exchange for their unexplored, confident alter egos. They wave goodbye to Jeff’s awkward all-male book club and Anne’s flailing attempts to catch the eye of Jeff’s sexy neighbor Max, and say hello to raucous summer nights filled with booze, dancing, and sex. Naturally things don’t exactly go according to plan.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Sargent Thomas Cavanaugh and his partners hunt down the murderers of one of their task force. But when their search leads them to a drug dealer and his psychopathic killer, Cavanaugh begins to realize they may be getting help from inside the police department.

When a series of haunting murders plagues a small Texas town, law officers Tex Holland and Pike McGraw lead the investigation. The murders turn out to be the most shocking and vile acts of sadism to ever hit the once peaceful community. With a dangerous killer on the loose re-enacting slave punishment on his victims, the cops must face their own personal demons as the murder spree throws them into a dangerous world of mercenary hillbillies and inbred cannibals.