Meet nine-year-old Kelly Marble. She never really meant to kill her parents.

Now in his sixties, Joe is released from the hospital after a long battle with pneumonia and forced to confront the harsh reality of his legacy: everyone he knew had assumed he was dead, and life had gone on around him without missing a beat. Returning to his old neighborhood in Chicago's 'Patch' district, he finds his car gone, all his worldly possessions pawned by his landlord, and the apartment he's lived in his entire adult life rented out to a single mother and her eight-year-old daughter.

Working-class father John Crowley is finally on the fast track to corporate success when his two young children are diagnosed with Pompe disease—a condition that prevents the body from breaking down sugar. With the support of his wife, John ditches his career and teams with unconventional specialist, Dr. Robert Stonehill to found a bio-tech company and develop a cure in time to save the lives of his children. As Dr. Stonehill works tirelessly to prove the theories that made him the black sheep of the medical community, a powerful bond is forged between the two unlikely allies.