Frédérique Letheil, who heads the research department of the Emmerson oil group, has sacrificed her private and sentimental life to her experiments. The management, which sees her work as a financial drain, has her unjustly dismissed by the group's general manager, Maxime Vergnaud. When the company realizes its mistake and the economic and ecological potential of Frédérique's research, it asks Maxime to bring her back at all costs.

The fierce and merciless battle of three forty-somethings who live together and want to seduce their pretty stewardess neighbor at all costs. A competition full of pitiful and feverish seduction acts. Redoing one's life at forty-five is not easy and becomes an absolute emergency. But does the stewardess really have the vocation to save the "Masculins 45"?