In the sixth film in the series, in February 1916, high school student Indy's plan of taking his girlfriend Nancy is sidetracked when a mysterious break-in, the theft of an electric motor, and rumors of German spies result in a mystery that only young Indy and Nancy can unravel. Indy and his father then head to the southwest to visit family in Albuquerque, where Junior is taken captive by Pancho Villa and his riders.

Two terrible lounge singers get booked to play a gig in a Moroccan hotel but somehow become pawns in an international power play between the CIA, the Emir of Ishtar, and the rebels trying to overthrow his regime.

New York's Odyssey Detective Agency is hired by two different clients to follow two women suspected of infidelity. Ladies' man John Russo trails Angela Niotes, the elegant wife of a wealthy Italian industrialist, while Charles Rutledge and Arthur Brodsky follow Dolores Martin, the beautiful young wife of a jealous husband. Their respective cases are complicated when John falls for Angela, and Charles falls for Dolores.

After undergoing radical surgery for injuries from a motorcycle accident, a young woman develops a strange phallic growth on her body and a thirst for human blood—the only nourishment that will now sustain her.