Achilles, a normal man infected with a disease that will bring down the Erebus rulers (human/machine hybrids) escapes back in time from 2410 to the present day where he has a chance to stop the Erebus from ever rising to power. However he is followed by the Erebus-7 who will stop at nothing to hunt him down.

The passengers on the Night Bus have many different stories -- some are lovers, some have dark secrets, some are looking for a fight, others are just trying to get through the night.