A small town is suddenly and inexplicably sealed off from the rest of the world by an enormous transparent dome. While military forces, the government and the media positioned outside of this surrounding barrier attempt to break it down, a small group of people inside attempt to figure out what the dome is, where it came from, and when (and if) it will go away.

A serious health scare ignites John Thomas, an insurance salesman in his 50s, to take a closer look at his life. Motivated by a misguided obsession with getting Barack Obama elected, John takes an overwhelming involvement in the Presidential campaign. While John becomes obsessed with the ideal of change that Obama represents for Americans, he has in turn neglected to create positive change in his own life, particularly with regard to his health and familial relationships. John hides his health problems from his strong, yet supportive wife, Molly, creating a strain on their marriage. John seeks the support of a Republican relative, MLK, who initially starkly resists supporting a Democratic candidate. John's son, Kalil, rebels against his father's avid support of Obama by supporting the Republican candidate as well. John neglects to support his daughter, Tamika, at a crucial moment in her life...