On the heels of booking a life-changing motion picture, a film director drives away his girlfriend and aggressively re-enters the LA dating scene.

A slightly unhinged former Navy SEAL lands a job as a police officer in Los Angeles where he's partnered with a veteran detective trying to keep maintain a low stress level in his life.

Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.

Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.

After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

Patrick Jane, a former celebrity psychic medium, uses his razor sharp skills of observation and expertise at "reading" people to solve serious crimes with the California Bureau of Investigation.