Still reeling from a heartbreaking family event and his parents' subsequent divorce, Tyler Hawkins discovers a fresh lease on life when he meets Ally Craig, a gregarious beauty who witnessed her mother's death. But as the couple draws closer, the fallout from their separate tragedies jeopardizes their love.

Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.