Ten years after signing off of one of TV's most iconic shows, Carly, Spencer, and Freddie are back, navigating the next chapter of their lives, facing the uncertainties of life in their twenties.

Best friends Lizzy (gay and a bit type-A) and Luke (straight and more laid back) are like family. When they were kids and both of their parents were getting divorces, they stuck together, and they've been there for each other ever since. Now, all grown up and still single, they've decided to start a family of their own. No, not like that (there are some lines even they won't cross) - we're talking the non-romantic, go-to-the-doctor's-office type of baby-making.

Obstetrician/gynecologist Mindy Lahiri tries to balance her personal and professional life, surrounded by quirky co-workers in a small medical practice in New York City.

The story of two teenage girls who discover they were accidentally switched as newborns in the hospital. Bay Kennish grew up in a wealthy family with two parents and a brother, while Daphne Vasquez, who lost her hearing at an early age due to a case of meningitis, grew up with a single mother in a working-class neighborhood. Things come to a dramatic head when both families meet and struggle to learn how to live together for the sake of the girls.

After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

Patrick Jane, a former celebrity psychic medium, uses his razor sharp skills of observation and expertise at "reading" people to solve serious crimes with the California Bureau of Investigation.

Jackie Moon is the owner, promoter, coach, and star player of the Flint Michigan Tropics of the American Basketball Association (ABA), the worst team in the league. In 1976 before the ABA collapses, the NBA plans to merge with the best teams of the ABA at the end of the season. Only the top four teams will make the move and the worst teams will fold. If the Tropics want to make it to the NBA, Jackie Moon must rally his team and start winning.