Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Tripp is a high school senior with a knack for building trucks who makes an incredible discovery - a gas-guzzling creature named Creech. To protect his mischievous new friend, Tripp hides Creech under the hood of his latest creation, turning it into a real-life super-powered Monster Truck. Together, this unlikely duo with a shared taste for speed team up on a wild and unforgettable journey to reunite Creech with his family.

John Gregory, who is a seventh son of a seventh son and also the local spook, has protected the country from witches, boggarts, ghouls and all manner of things that go bump in the night. However John is not young anymore, and has been seeking an apprentice to carry on his trade. Most have failed to survive. The last hope is a young farmer's son named Thomas Ward. Will he survive the training to become the spook that so many others couldn't?

There is a town in Maine where every story book character you've ever known is trapped between two worlds, victims of a powerful curse. Only one knows the truth and only one can break the spell. Emma Swan is a 28-year-old bail bonds collector who has been supporting herself since she was abandoned as a baby. Things change for her when her son Henry, whom she abandoned years ago, finds her and asks for her help explaining that she is from a different world where she is Snow White's missing daughter.

FBI Special Agent Olivia Dunham, brilliant but formerly institutionalized scientist Walter Bishop and his scheming, reluctant son Peter uncover a deadly mystery involving a series of unbelievable events and realize they may be a part of a larger, more disturbing pattern that blurs the line between science fiction and technology.