In Japan in the year 1600, at the dawn of a century-defining civil war, Lord Yoshii Toranaga is fighting for his life as his enemies on the Council of Regents unite against him, when a mysterious European ship is found marooned in a nearby fishing village.

Ford Brody, a Navy bomb expert, has just reunited with his family in San Francisco when he is forced to go to Japan to help his estranged father, Joe. Soon, both men are swept up in an escalating crisis when an ancient alpha predator arises from the sea to combat malevolent adversaries that threaten the survival of humanity. The creatures leave colossal destruction in their wake, as they make their way toward their final battleground: San Francisco.

There is a town in Maine where every story book character you've ever known is trapped between two worlds, victims of a powerful curse. Only one knows the truth and only one can break the spell. Emma Swan is a 28-year-old bail bonds collector who has been supporting herself since she was abandoned as a baby. Things change for her when her son Henry, whom she abandoned years ago, finds her and asks for her help explaining that she is from a different world where she is Snow White's missing daughter.

Acting on impulse, Claire Dennison (Willa Ford), enjoys a brief fling with a sexy stranger (a dead ringer for her husband), only to realize that the object of her desire is a crazed, manipulative, and tenacious psychopath.

When a cure is found to treat mutations, lines are drawn amongst the X-Men—led by Professor Charles Xavier—and the Brotherhood, a band of powerful mutants organised under Xavier's former ally, Magneto.