Tommy Burke, a good-natured young plumber who refers to his monkey wrench as his pipe organ, is unaware of his inferiority complex. One day he learns that an eccentric uncle has died, leaving him a brown derby said to bring good luck to its wearer. Meanwhile Edith Worthing and her Aunt Anna are expecting Edith's wealthy uncle, Adolph Plummer, from Australia. On a call to their house, Tommy is mistaken for the uncle, being announced as "a plumber," and soon a mutual romance develops with Edith. They are wedded by mistake when serving as witnesses to marriage by elopement. Farrell, a rival for Edith, learns of Tommy's deception and persuades Edith to elope with him; but Tommy follows in hot pursuit, in his pajamas and derby. At the last minute, a message arrives telling Edith that she and Tommy are already married.

Bank clerk John Hart is about to marry Mary Kelly, but she insists that before that happens he must grow a mustache. The idea of that shakes him up so much that he gets distracted at work, comes up short in his accounts and gets fired. Unable to find another job, he begins to work as an extra at a nearby film studio to earn money. One day the leading man of a picture John is working on gets into an argument with the director and storms off the set. Angered, the director sees John and, deciding that he'll show his arrogant star that he can make a movie idol out of just about anybody, picks John to replace him. As it turns out, John has a real talent for acting and before he knows it he becomes a star. Unfortunately, "stardom" isn't what John thought it would be.

Billy Morrow (Ben Lyon), who comes from a wealthy family, is sailing to Europe with his father (Holbrook Blinn) on their yacht. Along for the ride is Mrs. Parr (Claire Eames) and her stepdaughter. Near the French coast, Billy discovers that Mrs. Parr wants to arrange a marriage between him and the girl, so he escapes and takes a lifeboat ashore.

Lovers in Quarantine is an extant 1925 silent film comedy starring Bebe Daniels and directed by Frank Tuttle. It was produced by Famous Players-Lasky and distributed by Paramount Pictures. the film is based on a 1924 Broadway play Quarantine by F. Tennyson Jesse. It is preserved at the Library of Congress.

Director Frank Tuttle's 1925 silent mistaken-identity comedy, adapted from the 1923 play "Little Miss Bluebeard", stars Bebe Daniels.