The life of Sam Houston, soldier, statesman, patriot and one of the founders of the Republic of Texas, is depicted.

The U.S. Army and the Indians sign a peace treaty. However, a group of surveyors trespass on the Indians' land and violate the treaty. The army refuses to listen to the Indians' complaints, and the surveyors are killed by the Indians. A vicious Indian war ensues, culminating in an Indian attack on an army fort.

Custer's Last Fight chronicles George Armstrong Custer's final battle against the forces of Sitting Bull at the Battle of the Little Bighorn.

The prologue shows the life of a trapper, living in the solitude of the forest. He digs a bear trap, which is covered with boughs and grass. An Indian girl, armed with a bow and arrow, creeps close to a wild turkey, which she brings down. As she runs forward to gather up her prey she falls into the trap. Evans, the trapper, finds her there and on lifting her from the pit, finds that she has sprained her ankle, and takes her to his cabin, and makes her as comfortable as possible. As the shades of evening fall and the pain subsides, the girl drops into a slumber, and loath to awaken her, Evans leaves her in possession of his cabin and, wrapped in a blanket, sleeps outside. In the morning, the girl having recovered sufficiently, he lifts her to his horse, and mounting behind her, proceeds to the Indian camp. On the way he is attacked by a trio of Indians, who fire at him from behind a tree, and the trapper brings down one of his assailants.

American Indian Buffalo Big falls in love with the daughter of Colonel Sherry.

When Indians attack a white settlement, a brave kidnaps a white baby to give to his wife as a replacement for their dead baby. The white mother goes to the Indian camp to look for her child and is captured by the Indians who plan to torture her. The settlers attack the Indian camp, destroying it completely and killing the braves, while the Indian wife returns the baby to the white woman and allows her to escape. The Indian wife mourns her baby at its grave, unaware of the destruction of the Indian camp.

The emigrants are seen fighting the hordes of redskins. The hero rides to the settlement for help and engages in a thrilling duel with pursuing Indians. The settlers swoop down on the unprotected Indian village and burn it up. The savages seeing the flames, hurry back and fall into an ambush. They are attacked from the rear by the emigrants and from the front by the settlers. In a wild scene of carnage the surprised Indians are mowed down by the hail of bullets, horses and riders falling in tangled masses.