The Yukon is synonymous with wilderness, the gold rush, and also the toughest sled dog race in the world: The Yukon Quest. The series follows 7 dog teams as they attemps the 1000 mile race from Whitehorse, Yukon to Fairbanks, Alaska. Enormous challenges face the competitors: Four mountain summits, glaciers, overflowing rivers and lakes, wild animal encounters, six hours of daylight and temperature falling below -50 degrees Celsius. This race is not for the faint of heart and has been completed by fewer men and women than have climbed Mount Everest. It attracts only the most experienced and adventurous competitors from around the world.

After an archaeological team in Arizona unearths a werewolf skeleton and one of them develops symptoms of lycanthropy before dying, the dig's foreman, Yuri, tries to infect other townspeople as an experiment. When a science writer named Paul takes up residence in the town to cover the dig and develops a romantic interest in a female team member, Yuri makes Paul his next target.