Isolated in his austere penthouse overlooking Central Park, obsessive Wall Street data analyst Richard Boca sees ominous patterns. His computer models are behaving erratically, as are the swarms of mosquitos breeding in his apartment, an infestation that attends his psychological meltdown.

A pair of teenage girls in rural Pennsylvania travel to New York City to seek out medical help after an unintended pregnancy.

The New York office of the FBI brings to bear all their talents, intellect and technical expertise on major cases in order to keep their city and the country safe.

Recently divorced entrepreneur George Lopez is successful in his business ventures but caught between two cultures in his personal life. He struggles to find balance between the parenting demands of his Anglo ex-wife, Mackenzie, and the cultural expectations of his Latina mother, Alma. His freeloading Uncle Tio and Cousin Junior further complicate his life, which includes 11-year-old son Harper. Outside the home, the successful businessman gives back to the community by teaching history to a multicultural class at a Los Angeles night school; there he is supervised by tough, attractive Assistant Principal Concepcion.

Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.

Andrea, a grieving Chicana mother, confronts an uninvited family member before her Día de los Muertos celebration. By night's end, death offers her a choice that she couldn't make in life.