Speak No Evil is the story of Anna, a single mother fighting to protect her daughter from demonically possessed children and a town gone mad.

The plot centers around the Johnson family (consisting of Chris (Rob Hartz) and Ellen (Kathleen Cameron) Johnson, and their son Casey (Hy Rillero)) of Los Angeles, California, one of a small number of families to survive a global pandemic that, according to the opening of the film, occurs "sometime in the future..." The disease began as a particularly virulent flu strain in Southeast Asia. Efforts made to contain the virus in that portion of the world are ineffective as global transportation networks carry infected individuals all around the world. Hospitals become overloaded, and the public works infrastructure begins to shut down. Eventually, the main characters leave L.A., encountering many hardships along the way. They make it to a friendly small town, where life begins again.

Defense attorney Jennifer Garrick acquires a Pinocchio puppet from a condemned serial killer. Her pre-teen daughter, Zoe, mistakes the puppet as a birthday present and grows attached to her new friend. Suddenly, accidents begin to happen to those who cross Zoe. Zoe claims it's her Pinocchio doll but her therapist thinks otherwise. Pinocchio promises he'll behave if Zoe will cut his strings...