A deodorant company with a product called "Smell No Mo" pits two rival ad agencies in a race to come up with a campaign for a new-fangled sanitary napkin called Vorcan. The advertising satire follows the New York firm of Cranston & Co. as they fight rival Hoffman & Partners. Cranston fires his creative director which puts a young copywriter with a literature degree on the front line, even though he doesn't want to be. The contest comes down to a schmaltzy campaign by Hoffman with music by Air Supply that uses the tagline "Vorcan: your own personal air supply." or a more down to earth campaign from Cranston of "The pad ain't bad!"

America's three top leisure-time activities come roaring to life in National Lampoon's Favorite Deadly Sins. This film consists of three short stories: Greed (Joe Mantegna), Anger (Andrew Clay) and Lust (Denis Leary).

A self-help guru's televised teachings inspire a down-and-out businessman to pursue his dream of making a movie.

Peter and Katherine Witner are Southern California super-yuppies with great jobs but no center to their lives. When they both lose their jobs and begin marital infidelities, their solution is to start their own business together. In order to find meaning to their empty lives, they follow various New Age gurus and other such groups. Eventually, they hit rock bottom and have to make some hard decisions.