Two goofy Australian musicians take to the American Blues Trail to confront the mysterious legend of the crossroads. A search for the true soul of the Blues begins, as two friends discover they are facing a crossroads in their own lives.

The story of The Blues traces the four main traditions of blues music: Form Blues, Blues, Urban Blues and Blues Electric. The blues has evolved and diversified, and filtered into a surprising variety of styles in contemporary music. In the blues the history of music was released. A look at the roots, origins and the subsequent influence of style the film explores the blues significant contribution to the development of jazz, rock and country and western music. Big Bill Broonzy, Robert Johnson, Lonnie Johnson, Blind Lemon Jefferson, Alexander Texas, and many more artists are featured through the film.

Hellhounds On My Trail is a tribute to the influence of Delta Blues legend Robert Johnson and the effect that he has had on today's music. The film was made in conjunction with the "American Masters Series" week-long tribute put on by the Rock and Roll Hall of Fame and chronicles the legacy of Robert Johnson through interviews and speeches by a number of musicologists and through the performances of Robert Johnson's work by a number of fairly popular contemporary artists. The film features performances from Rob Wasserman and Bob Weir from the Grateful Dead; Keb' Mo; Robert Lockwood Jr.; G Love and Special Sauce; Gov't Mule and a lot of other performers.