A family man who turns out to be a retired mob enforcer must travel across the country to find his daughter who has gone missing.

A fanatical animal rights activist releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger feeds experimental steroids to wild alligators so they can fight back. The giant pythons and gargantuan alligators go on a killing spree, and it is now left up to the two feuding women to put aside their differences to put a stop to the creatures and the destruction.

With songs, dancing and backstage antics, The Muppets and Disney Channel's biggest stars team up for another fun variety show.