An airline pilot and his wife are forced to face the consequences of her alcoholism when her addictions threaten her life and their daughter's safety. While the woman enters detox, her husband must face the truth of his enabling behavior.

This documentary on the nightlife of Las Vegas was filmed primarily at the Topicana and Dunes Hotels, respectively, in 1962-63. Musical numbers performed by the film's stars aside, "Spree" also includes scenes of gambling casinos, cock fights and boxing.