Andreas, an Art History Professor at the Athens School of Fine Arts, is involved both with a sexy intellectual French-Greek woman and a young student of his despite being in love with his beautiful wife. When he finds out he has leukemia and only a few months to live, he decides to keep it a secret but also to talk to the women in his life about his infidelity.

Nikos, Christine, Homer, George, Regina, Dimitris, Jim, Margaret, Elias, Monika and Haris return from their summer holidays.

Rival Chicago reporters Sabrina Peterson and Peter Brackett join forces to uncover a train wreck conspiracy.