Death stalks the fogbound streets of Victorian London: young women are going missing, horribly mutilated bodies are found floating in the Thames and criminal gangs terrorize the innocent. At the heart of this tangled web sits the mysterious Li H'sen Chang, sorcerer and hypnotist, and his grotesque sidekick Mister Sin. The Doctor dons deerstalker hat and cape to seek out the sinister force lurking in the shadows of the metropolis, for the Talons of Weng-Chiang are reaching out to shred the human race.

Sweethearts Brad and Janet, stuck with a flat tire during a storm, discover the eerie mansion of Dr. Frank-N-Furter, a transvestite scientist. As their innocence is lost, Brad and Janet meet a houseful of wild characters, including a rocking biker and a creepy butler. Through elaborate dances and rock songs, Frank-N-Furter unveils his latest creation: a muscular man named 'Rocky'. Harriet then spawns in and says hello and the credits roll!

The adventures of The Doctor, a time-traveling humanoid alien known as a Time Lord. He explores the universe in his TARDIS, a sentient time-traveling spaceship. Its exterior appears as a blue British police box, which was a common sight in Britain in 1963 when the series first aired. Along with a succession of companions, The Doctor faces a variety of foes while working to save civilizations, help ordinary people, and right many wrongs.