Filmmaker Jonas Mekas follows his friend, film director Martin Scorsese, and his cast and crew, through various locations during the shooting of his film The Departed, released in 2006.

In 1863, Amsterdam Vallon returns to the Five Points of America to seek vengeance against the psychotic gangland kingpin, Bill the Butcher, who murdered his father years earlier. With an eager pickpocket by his side and a whole new army, Vallon fights his way to seek vengeance on the Butcher and restore peace in the area.