Lady Caroline Faye meets Lord Vane Brecon and is attracted to him. When she finds out that he is being accused of a murder he did not commit, she sets out to prove him innocent

In 1938, an art collector appeals to eminent archaeologist Dr. Indiana Jones to embark on a search for the Holy Grail. Indy learns that a medieval historian has vanished while searching for it, and the missing man is his own father, Dr. Henry Jones Sr.. He sets out to rescue his father by following clues in the old man's notebook, which his father had mailed to him before he went missing. Indy arrives in Venice, where he enlists the help of a beautiful academic, Dr. Elsa Schneider, along with Marcus Brody and Sallah. Together they must stop the Nazis from recovering the power of eternal life and taking over the world!