After accidentally killing his lead star, a has-been hollywood producer turns to an ancient herbal elixir, in the hope that it will save his career. He makes a dark deal that unleashes a band of bloodthirsty, shape-shifting, ferocious beasts on LA.

Phil and his misfit friends score big when they are invited to the party of the century at Bob's house. Known for throwing the craziest drug, sex and booze filled parties, this was sure to be a night to remember. The only problem is that they can't remember a thing. When Phil wakes up realizing that his girlfriend is only hours from knocking on his door, he decides to enlist the help of his friends to try to piece together what was obviously a night worth remembering.

In danger of losing his badge, a big city detective agrees to aid a small town sheriff in a routine missing persons investigation only to discover that at least one girl has gone missing in this sleepy fishing town each year for the last twenty years. When a body finally emerges on the lake and suspects literally crawl out of the hills, the two lawmen realize they’re being toyed with and to make things worse, the killer seems to have set his eyes on a group of sorority girls who are not only isolated by the lake, but have their own nefarious plans in mind. Outnumbered and out of options, the two lawmen must solve the mystery of the missing girls or suffer the same fate.