The story of a New York pro baseball team and two of its players. Henry Wiggen is the star pitcher and Bruce Pearson is the normal, everyday catcher who is far from the star player on the team and friend to all of his teammates. During the off-season, Bruce learns that he is terminally ill, and Henry, his only true friend, is determined to be the one person there for him during his last season with the club. Throughout the course of the season, Henry and his teammates attempt to deal with Bruce's impending illness, all the while attempting to make his last year a memorable one.

Dr. Harvey Wallinger is one of Nixon's aides who rises through the ranks to become the "real" power behind the president.

Dr. Bock, the chief of medicine at a Manhattan hospital, is suicidal after the collapse of his personal life. When an intern is found dead in a hospital bed, it appears to Bock to be a case of unforgivable malpractice. Hours later, another doctor, who happens to be responsible for another case of malpractice, is found dead. Despondent, Bock finds himself drawn to Barbara, the daughter of a comatose missionary.

A smart-mouthed junkie and a former hairdresser spends his days looking for just "one more fix".