Comedy about one big happy family and their sometimes awkward, often hilarious and ultimately beautiful milestone moments as told by its various members. Of the three siblings, middle child Matt may have just found his true love, his co-worker, Colleen; his coddled youngest brother, Greg, and his wife, Jen, are overwhelmed by the birth of their first child; and the eldest, Heather, and her husband, Tim, are dreading their impending empty nest so much, they're considering having another baby. Their parents are Joan the family's adoring matriarch who would do anything for her kids - as long as she agrees with it - and John, the gregarious patriarch who's searching for ways to soften the blow of turning 70. As the family's lives unfold in four short stories each week, they try to savor these little pieces of time that flash by but stay with you forever, because these moments add up to what life's all about.

Liza Miller, a suddenly single stay-at-home mother, tries to get back into the working world, only to find it’s nearly impossible to start at the bottom at 40-year old. When a chance encounter convinces her she looks younger than she is, Liza tries to pass herself off as 26 and lands a job as an assistant at Empirical Press. Now she just has to make sure no one finds out the secret only she and her best friend Maggie share.

The team of people who saved Winter's life reassemble in the wake of her surrogate mother's passing in order to find her a companion so she can remain at the Clearwater Marine Hospital.

Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.