When CIA analyst Jack Ryan stumbles upon a suspicious series of bank transfers his search for answers pulls him from the safety of his desk job and catapults him into a deadly game of cat and mouse throughout Europe and the Middle East, with a rising terrorist figurehead preparing for a massive attack against the US and her allies.

Ruth Duffy is getting by on an assistant's salary at a pricey school for girls in Manhattan, managing to move beyond the trouble and loss of her teenage years. Jonny Collins is working local jobs near the Throgs Neck Bridge in the Bronx. When they cross paths after years apart, Jonny is as consumed with Ruth as he was in their high school days, and he infiltrates her life for love and profit.

In 2002, cable news producer Kim Barker decides to shake up her routine by taking a daring new assignment in Kabul, Afghanistan. Dislodged from her comfortable American lifestyle, Barker finds herself in the middle of an out-of-control war zone. Luckily, she meets Tanya Vanderpoel, a fellow journalist who takes the shell-shocked reporter under her wing. Amid the militants, warlords and nighttime partying, Barker discovers the key to becoming a successful correspondent.

Sexy New York detective and single mother Harlee Santos fell in with a tight-knit group of dirty cops, taking bribes and protection money that she uses to provide the best life for her honest, talented daughter. But when she's trapped by the FBI and forced to inform on her own "brothers," she'll have to walk the fine line between love, loyalty, honor and betrayal, and try to keep it together for her daughter's future.

After years away from the CIA, Elizabeth McCord is pulled back into the political arena. The newly appointed Secretary of State is tough, fair, and smart, driving international diplomacy, wrangling office politics, and circumventing protocol as she negotiates global and domestic issues, both at the White House and at home.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Martin Bohm, a widower and single father, is haunted by an inability to connect to his autistic, mute 11-year-old son, Jake. Their relationship and their lives take an extraordinary turn when he discovers his gifted son has the ability to see things that no one else can and the patterns that connect seemingly unrelated events.

John Reese, former CIA paramilitary operative, is presumed dead and teams up with reclusive billionaire Finch to prevent violent crimes in New York City by initiating their own type of justice. With the special training that Reese has had in Covert Operations and Finch's genius software inventing mind, the two are a perfect match for the job that they have to complete. With the help of surveillance equipment, they work "outside the law" and get the right criminal behind bars. 

After the unexpected death of her husband, a suburban mom resorts to selling weed to support her family.