Lisa Dolittle sends her daughter to 'Durango', a Dude Ranch, to find herself. While there, she uses her talent to talk to the animals in order to save Durango from being taken over by a neighboring Ranch.

Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.