It’s 1958 Manhattan and Miriam “Midge” Maisel has everything she’s ever wanted - the perfect husband, kids, and Upper West Side apartment. But when her life suddenly takes a turn and Midge must start over, she discovers a previously unknown talent - one that will take her all the way from the comedy clubs of Greenwich Village to a spot on Johnny Carson’s couch.

After a chance encounter online, Caleb meets and falls head over heels for Jeremy. Soon the line between love and lies blur. Struggling to keep his past a secret, including his mentally ill mother, Caleb slowly succumbs to his darker side. A sudden turn of events finds Jeremy held captive, until Caleb's quest for the truth is revealed.