Leonard (Martin Starr - 'Freaks & Geeks', 'Knocked Up', and 'Party Down'), exists in slow motion but lives in a regular speed world. When he discovers his office crush is getting transferred to Florida, Leonard decides he must somehow become regular speed to win her heart before she leaves town for good.

William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.