In the 1840s, Ramsey MacKay, the driver for the struggling Wells Fargo mail and freight company, will secure an important contract if he delivers fresh oysters to Buffalo from New York City. When he rescues Justine Pryor and her mother, who are stranded in a broken wagon on his route, he doesn't let them slow him down and gives the ladies an exhilirating ride into Buffalo. He arrives in time to obtain the contract and is then sent by company president Henry Wells to St. Louis to establish a branch office.

When a young woman named Barbara Clarke has an affair with adventurer Roger Coverman, it causes a scandal in the Puritanical town of Salem, Massachusetts. After a meddling girl arouses their suspicions, the town's elders accuse Barbara of being a witch. She is tried, convicted of sorcery and sentenced to death. As the townspeople prepare to burn Barbara at the stake, Roger tries desperately to save the woman he loves.

A dog accused of murdering sheep is brought to trial.