An intimate look at the lives and legacies of piano player Pinetop Perkins, drummer Willie 'Big Eyes' Smith and guitarist Hubert Sumlin, all Muddy Waters and Howlin' Wolf sidemen. The film captures some of the last interviews and their final live performances together, before their deaths in 2011. The historic live shows are accompanied by performances and personal insights from many of the blues and rock stars these legendary sidemen inspired including; Bonnie Raitt, Gregg Allman, Derek Trucks, Shemekia Copeland, Kenny Wayne Shepherd, Joe Perry, Joe Bonamassa and Johnny Winter.

Interviews and performances by the men who shaped the tough urban blues sound of Chicago. Dick Gregory provides the commentary, whilst sessions are provided by Muddy Waters, Johnnie Lewis, Floyd Jones, Buddy Guy, Junior Wells and J.B. Hutto.

On February 7th, 2003, renowned artists across multiple music genres and generations commandeered the stage at New York City's Radio City Music Hall to pay tribute to their common heritage and passion - the blues. Shared with thousands of fans in attendance, legendary performers from roots, rock, jazz and rap joined forces for a once-in-a-lifetime "Salute To The Blues" benefit concert whose proceeds went to musical education.