Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.

Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

In 1934, the second most lucrative business in New York City was running 'the numbers'. When Madam Queen—the powerful woman who runs the scam in Harlem—is arrested, Ellsworth 'Bumpy' Johnson takes over the business and must resist an invasion from a merciless mobster.