Mary Ann returns to present-day San Francisco and is reunited with her daughter and ex-husband, twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture-perfect Connecticut life created, Mary Ann is quickly drawn back into the orbit of Anna Madrigal, her chosen family and a new generation of queer young residents living at 28 Barbary Lane.

Following a year in the life of James Sanchez, it's a story about a guy rapidly approaching thirty, who doesn't have a six-pack, full head of hair or a boyfriend. While his best friend Roxy, an actress-turned-activist, struggles with showing him there's life beyond the glitz of the disco ball, his other friend, Brandon, one of those gay boys comfortable in his own gay skin, works on getting James to at least talk to a boy. Feeling out of place in the world of circuit boys, caught between his Hispanic-American heritage and being gay, we watch James find his place in the world, realizing that life is in the journey, not the destination.

In 1950's Hollywood, movie star Guy Stone must marry a studio secretary in order to conceal his homosexuality. Sally has no idea her marriage is a sham, though, and turns Guy's life upside-down. However, soon after the wedding, Guy develops feelings for a writer named Rick.

In the criminal justice system, sexually-based offenses are considered especially heinous. In New York City, the dedicated detectives who investigate these vicious felonies are members of an elite squad known as the Special Victims Unit. These are their stories.