Needle paints a harrowing picture of a Liverpool overrun by drugs, charting a young man's nightmarish descent into intravenous heroin use and AIDS and a police and political leadership incapable of the imagination or courage necessary to respond to the drug problem.

After seeing her husband fail in fighting a battle to keep his factory open, a manageress loses her job in a disagreement with the manager over sexual harassment of her staff. She accepts the advice of her father and joins his son, a left-wing organizer, and takes her plight to the union.