In the midst of a global epidemic, Annie finds herself the sole carer of her eight-year-old nephew, but he has questions only a mother can answer.

The story of Hugh Knight, a rising heart surgeon who is gifted, charming and infallible. He is a hedonist who, due to his sheer talent, believes he can live outside the rules. His "work hard, play harder" philosophy is about to come back and bite him.

Troubled psychotherapist Peter Bowers is suffering from nightmares and eerie visions. When he uncovers a horrifying secret that all of his patients share, he is put on a course that takes him back to the small hometown he fled years ago. There he confronts his demons and unravels a mystery 20 years in the making.

Aishe sees her father kiss his new love for the first time since her mother's death. Unable to sleep she wakes up her younger sister for company.

The lives of staff at the fictional Kings Cross Hospital and the wild streets of Darlinghurst in the 1960s. Joan Miller is a smart and sophisticated midwife who returns home from London to take a job at the Kings Cross Hospital. Dr Patrick McNaughton is a charismatic head of obstetrics at Kings Cross Hospital. Frances Bolton is the tough matron who also controls the running of Stanton House, a home for unwed pregnant young women.

Running the remote Hope Island Clinic, Sam Stewart is an accomplished doctor, who with her team, looks after the residents of all the neighbouring islands, as well as the holidaymakers and thrill seekers who visit the area. Not only a GP, Sam is a single mother with a free spirit and a determination – who has an unusual hobby: venom.

At Sydney's National Dance Academy, a few talented youngsters are recruited for the excruciatingly tough course. It follows Tara Webster, a sheepfarmgirl who's ambition is to be the next best ballerina. Jewish long line of doctors' heir Samuel 'Sammy' and minor juvenile offender Christian are the outsiders but gradually fit in, making new kinds of friends. Star ballerina's daughter Kat also introduces them in the circle of last-year brother Ethan, who already aspires a career as choreographer. Also Abigail, a smart young girl who'll walk over dead bodies to reach the stars tries to sabotage everything and everyone.

This compelling series investigates the motives and m.o. of female murderers. While males are often driven by anger, impulse and destruction, women usually have more complex, long-term reasons to kill.