Earth is visited by an alien species that threatens humanity's existence. Events unfold in real time through the eyes of five ordinary people across the globe as they struggle to make sense of the chaos unraveling around them.

A detective in a small Pennsylvania town investigates a local murder while trying to keep her life from falling apart.

The detectives of the Organized Crime Control Bureau work to dismantle New York City's most vicious and violent illegal enterprises.

Angel is released from juvenile detention on the eve of her 18th birthday. Haunted by her past, she embarks on a journey with her 10 year-old sister that could destroy their future.

A girl learns the brutal sacrifices it takes to satisfy her love.

John Reese, former CIA paramilitary operative, is presumed dead and teams up with reclusive billionaire Finch to prevent violent crimes in New York City by initiating their own type of justice. With the special training that Reese has had in Covert Operations and Finch's genius software inventing mind, the two are a perfect match for the job that they have to complete. With the help of surveillance equipment, they work "outside the law" and get the right criminal behind bars. 

After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

When Buy More computer geek Chuck Bartowski unwittingly downloads a database of government information and deadly fighting skills into his head, he becomes the CIA's most vital secret. This sets Chuck on a path to become a full-fledged spy.

A covert team of special forces operatives risk their lives on undercover missions around the globe, while their wives maintain the homefront, protecting their husbands' secrets.

Newlywed Melinda Gordon tries to help the dead communicate with loved ones, but sometimes the messages she receives are intense and confusing. Most of Melinda's efforts involve resolving conflicts that are preventing the spirits from passing over.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.