Eddie James, a disgruntled actor who wants to do more than play "Mulligan the Rabbit" on a children's TV show, discovers life can change in a heartbeat when he accidentally gets into a car accident with single mother Annie Baker. In the unexpected friendship that develops between them, Eddie tries to help Annie's nearly-blind daughter Taylor get an operation to restore her sight.

Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.

When Buy More computer geek Chuck Bartowski unwittingly downloads a database of government information and deadly fighting skills into his head, he becomes the CIA's most vital secret. This sets Chuck on a path to become a full-fledged spy.