Ciao Darwin is a variety game show format from Italy sold under licence to several countries, including Romania, Hungary, Poland, Serbia, Canada, USA, China and Greece. There are two competing teams of about 50 people each, usually made up of people who fit certain opposing stereotypes. In each game two members of the audience are selected at random, one from each team, indicated by a light in front of them which remains illuminated when all the other team members' lights have gone off. The games involve contestants competing in acts of bravery, style and talent, some of which are designed to humiliate the contestants, especially an assault course which was introduced with the Italian version in 2010, and the Finale which is a water tank game.

Saverio and Filippo are two friends and religious leaders of a travel agency in Rome. However, Filippo has trouble with his wife, because she finds out that he cheated on her with a comely girl named Alice.